Air pollution second largest cause of death in Africa

Air pollution was responsible for 1.1 million deaths across Africa in 2019, a new study shows. Most of these deaths — 697,000 — were as a result of household air pollution driven largely by indoor cooking stoves.

But while household air pollution is the predominant form of pollution, it is declining, whereas outdoor or ambient air pollution is increasing, signalling a a looming problem, said Boston College professor of Biology Philip Landrigan, who led the project with United Nations Environment Programme Chief Environmental Economist Pushpam Kumar.

According to the report, air pollution is the second largest cause of deaths in Africa. It is a major threat to health, human capital, and economic development, and was responsible for 16·3 percent of all deaths.

Outdoor air pollution resulting from sources like exhaust smoke and pollutants emitted by industries claimed 394,000 lives on the continent.

Air pollution is responsible for more deaths than tobacco, alcohol, road accidents, and drug abuse. Only HIV/Aids causes more deaths.

But besides the loss to life, air pollution from smog-inducing ozone and fine particles may be siphoning billions of dollars off the continent’s economy each year.

Thanks to sustained interventions by governments, non-governmental organisations, and UN agencies, disease and deaths from household air pollution across Africa are now declining, albeit slowly and unevenly. Polluting fuels such as charcoal and kerosene are still prevalent.

Deaths attributable to air pollution result from lower respiratory infections stand at 336,460 deaths, ischemic heart disease — related to blockage in the arteries — (223,930), neonatal disorders (186,541), chronic obstructive pulmonary disease (70,479), and stroke (193,936).

The report also associates air pollution to far-reaching effects of diminishing intellectual development of Africa’s children.

According to the research, economic output lost to air pollution related disease wiped about $3 billion off of Ethiopia’s economy, that is 1.16 percent of the nation’s Gross Domestic Product; $349 million was lost from the Rwandan economy (1.19 percent of GDP) and $1.6 billion in Ghana (0.95 percent of GDP).

In the first continent-wide examination of the far-reaching impacts of this pollution, the assessment aimed to quantify how air pollution is affecting health, human capital, and economies, but with a particular focus on three rapidly developing sub-Saharan countries: Rwanda, Ethiopia and Ghana.

The report — International Day of Clean Air for blue skies — published on October 7 in the latest edition of the journal The Lancet Planetary Health, indicates that patterns of air pollution-related disease and death vary across Africa. The highest rates are seen in countries with the lowest social development indices.

An upward trend in ambient air pollution-related mortality is evident in Ghana, the most economically advanced of the three countries we examined in detail, and is beginning to emerge in Ethiopia and Rwanda.

Differences in air pollution-related disease and death are seen by gender, with 43 percent of ambient (outdoor) air pollution related deaths and 47 percent of household air pollution related deaths occurring in women.

In the three countries that are the focus of this analysis, household air pollution exposures are greatest in Ethiopia and Rwanda, where an estimated 98 percent of households burn solid fuels for cooking and heating.

“The most disturbing finding was the increase in deaths from ambient air pollution,” said Landrigan

“While this increase is still modest, it threatens to increase exponentially as African cities grow in the next two to three decades and the continent develops economically.”

And the problem could get even worse with burgeoning population numbers on the continent.

With Africa’s population on track to more than triple in this century, from 1.3 billion in 2020 to 4.3 billion by 2100, cities are expanding, economies are growing, and life expectancy has almost doubled, note the researchers. Which they say could be problematic.

Already, fossil fuel combustion has driven an increase in outdoor air pollution that in 2019 killed 29.15 people per 100,000 population, an increase from 26.13 deaths per 100,000 in 1990, according to the report.

The report warns air pollution will increase morbidity and mortality, diminish economic productivity, impair human capital formation, and undercut development if no intervention is made.

Air pollution second largest cause of death in Africa – Daily Monitor
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Study finds living near oil, gas wells increases air pollution exposure

Stanford researchers have observed higher levels of air pollutants within 2.5 miles of oil and gas wells, likely worsening negative health outcomes for residents.

Stanford researchers have observed higher levels of air pollutants within 2.5 miles of oil and gas wells, likely worsening negative health outcomes for residents. The findings of the study were published in the journal ‘Science of The Total Environment’.

The scientists analysed local air quality measurements in combination with atmospheric data and found that oil and gas wells are emitting toxic particulate matter (PM2.5), carbon monoxide, nitrous oxide, ozone and volatile organic compounds (VOCs).

The findings will help researchers determine how proximity to oil and gas wells may increase the risk of adverse health outcomes, including preterm birth, asthma and heart disease. “In California, Black and Latinx communities face some of the highest pollutions from oil and gas wells. If we care about environmental justice and making sure every kid has a chance to be healthy, we should care about this. What’s novel about our study is that we’ve done this at a population, state-wide scale using the same methods as public health studies,” said lead author David Gonzalez, who conducted research for the study while a PhD student in Stanford’s Emmett Interdisciplinary Program in Environment and Resources (E-IPER). The findings align with other smaller-scale studies that have measured emissions from a handful of wells. At least two million Californians live within one mile of an active oil or gas well. “It’s really hard to show air quality impacts of an activity like oil and gas production at a population scale, but that’s the scale we need to be able to infer health impacts,” said senior study author Marshall Burke, an associate professor of Earth system science at Stanford’s School of Earth, Energy and Environmental Sciences (Stanford Earth).

“While it’s not necessarily surprising that drilling and operating oil and gas wells emit air pollutants, knowing the magnitude of the effect improves our broader understanding of who is exposed to what and how to intervene to improve health outcomes,” added Burke. The research has revealed that when a new well is being drilled or reaches 100 barrels of production per day, the deadly particle pollution known as PM2.5 increases by two micrograms per cubic meter about a mile away from the site.

A recent study published in ‘Science Advances’ found that long-term exposure to one additional microgram per meter cubed of PM2.5 increases the risk of death from COVID-19 by 11 per cent. “We started in 2006 because that’s when local agencies started reporting PM2.5 concentrations. We’re very concerned about the particulate matter because it’s a leading global killer,” said Gonzalez, who is now a postdoctoral researcher at the University of California, Berkeley.

The team evaluated about 38,000 wells that were being drilled and 90,000 wells in production between 2006 and 2019. They developed an econometric model incorporating over a million daily observations from 314 air monitors in combination with global wind direction information from the National Oceanic and Atmospheric Administration (NOAA) to determine if the pollutants were coming from the wells. Other factors that could be contributing to elevated emissions were controlled for — such as wildfire smoke or industrial activities — and monitors located far from drilling sites were used to identify those factors unrelated to wells. They also analysed locations with air quality data from both before and after a well was drilled.

“Sometimes the wind is blowing from the well, sometimes it’s not, and we found significantly higher pollution on days when the wind is blowing from the wells. As a control, we assumed wells that are downwind of the air monitor shouldn’t contribute any pollution — and that is indeed what we saw,” Gonzalez said. The research also revealed that ozone — a powerful oxidant that can cause wheezing, shortness of breath and aggravated lung disease — was present up to 2.5 miles from wells. Children are at the greatest risk from exposure to ozone because their lungs are still developing, according to the Environmental Protection Agency (EPA).

The new study contributes to a growing body of evidence about the dangers of living near oil and gas wells that may help guide ongoing policymaking around residential setbacks from drilling sites. For example, LA County recently voted to phase out oil and gas drilling, citing issues of climate change, environmental impacts and equity, and other California cities are in discussion about neighbourhood drilling regulations. “Many of California’s oil fields have been operating for decades. People that live near them have been chronically exposed to higher levels of pollution — and a lot of these wells are located in neighbourhoods that are already burdened by pollution,” Gonzalez said.

“Our study adds to the evidence that public health policies are needed to reduce residents’ exposure to air pollution from wells,” Gonzalez added. Although data for the research is from California, the co-authors say the findings are likely applicable to other regions with oil and gas operations.

“We’ve had earlier papers suggesting that proximity to oil and gas production worsens health outcomes, and the likely channel was through air pollutants, but we previously didn’t have a good way to demonstrate that was the case,” Burke said. “This new work is helping confirm that air pollution was the missing link between this type of energy production and the bad outcome that we cared about,” Burke concluded.

Study finds proteins that support photosynthesis in iron-deficient plants
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Pollution’s impact on child health

Summary: Air pollution is known to harm children’s respiratory health, but its specific impacts on infection rates have remained unclear. A new analysis provides evidence of a link between the two in low-income settings, and indicates one industry may play an outsized role in the problem.

Studies have shown air pollution is a major risk factor for respiratory infection — the leading cause of death among children under five — but bad air’s specific impacts on developing bodies have remained somewhat of a mystery.

A Stanford-led study reveals a link between tiny airborne particles and child health in South Asia, a region beset with air pollution and more than 40 percent of global pneumonia cases. The analysis, published in Environmental Pollution, estimates the effect of increased particulate on child pneumonia hospitalizations is about twice as much as previously thought, and indicates a particular industry may play an outsized role in the problem.

The findings could help public health officials and policymakers better target emissions reduction programs to improve child health.

“Everybody wants to protect kids’ health,” said study lead author Allison Sherris, a postdoctoral research fellow in Earth system science at Stanford’s School of Earth, Energy & Environmental Sciences. “Now, we have evidence of a clear health benefit to children from reducing ambient PM2.5 emissions in Dhaka.”

For many of the 21 million residents of Dhaka, Bangladesh — the study’s focus area — air pollution is an all-too-regular part of life, especially in winter, when coal-burning brick kilns around the city operate. Of special concern is PM2.5, airborne particles 2.5 micrometers wide or smaller. The larger of these particles are about one-thirtieth the width of a human hair, small enough to inhale deep into the lungs.

Once inside the lungs, these particles can cause inflammation and impair the body’s ability to fight infection. But particles from different sources can have different shape, size and chemical composition, and it’s not clear what specific components of PM2.5 might be most harmful.

Few studies have evaluated the health effects of PM2.5 in infants and young children, especially in low-income countries where children are more than 60 times as likely to die from air pollution exposure as children in high-income countries, according to the World Bank. Among studies that have, most focused on the indoor environment, where the use of biomass-burning cookstoves has been associated with child respiratory infection.

“Specifying the impact of industry-generated air pollution on child health provides compelling evidence to support interventions to reduce pollution,” said study senior author Stephen Luby, a professor of infectious diseases at Stanford University. “This is often more salient to politicians than the marginal contribution of emissions to global climate change.”

Sherris, Luby and their colleagues analyzed long-term PM2.5 monitoring data alongside community health surveillance of respiratory infections from the Atomic Energy Centre, Dhaka, and the International Centre for Diarrhoeal Disease Research, Bangladesh. They found pneumonia incidence among children under 5 increased by 3.2 percent for every PM2.5 increase of 10 micrograms per cubic meter of air — a standard measure in air pollution analysis.

The mean PM2.5 level in Dhaka was on average over three times higher than the World Health Organization standard. The association between air pollution and child pneumonia suggests that air pollution is a major contributor to the leading cause of child death in Bangladesh and across South Asia.

That difference equates to more than 200,000 additional child pneumonia cases in Bangladesh each year, and nearly two million additional cases across South Asia. The increase is also approximately double similar prior estimates of pneumonia hospitalizations associated with increased PM2.5 and about 10 times more than such estimates for outpatient visits.

The difference from previous findings may reflect the young age of the study population — most children in the study were two or younger — the source composition of particulate matter in Dhaka, and the fact that the study included nearly all community infection cases, rather than just focusing on cases that made it to clinics and hospitals.

Prior studies by researchers at the Atomic Energy Centre, Dhaka found that biomass burning contributed the most to outdoor PM2.5 levels, followed by brick kiln emissions and soil dust. However, on days when brick kilns contributed a heavier than-usual amount of PM2.5 to the mix of bad air, the link between PM2.5 and child pneumonia was stronger.

The findings are among the first evidence that communities and policymakers can point to that suggests a measurable impact of brick kilns on child health. Considering 9 out of 10 people live in areas with air pollution exceeding World Health Organization guidelines, further investigation into whether particles from brick kilns and other sources have different health impacts could inform health and environmental interventions around the world. Luby leads a collaboration among public health experts, industry stakeholders, technology consultants and government agencies to improve the industry. He received funding for related work focused on brick kilns and other industries, funded by the Sustainability Initiative that gave rise to Stanford’s new school focused on climate and sustainability.

“We’re still only looking at a small slice of the potential health outcomes that might be linked to this kind of air pollution, and we still lack perfect measurements of exposure to it,” said Sherris. “The true health burden is likely much greater.

Pollution’s impact on child health — ScienceDaily
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Study reveals a link between air pollution and child health

Studies have shown air pollution is a major risk factor for respiratory infection – the leading cause of death among children under five – but bad air’s specific impacts on developing bodies have remained somewhat of a mystery.

A Stanford-led study reveals a link between tiny airborne particles and child health in South Asia, a region beset with air pollution and more than 40 percent of global pneumonia cases. The analysis, published in Environmental Pollution, estimates the effect of increased particulate on child pneumonia hospitalizations is about twice as much as previously thought, and indicates a particular industry may play an outsized role in the problem.

The findings could help public health officials and policymakers better target emissions reduction programs to improve child health.

“Everybody wants to protect kids’ health. Now, we have evidence of a clear health benefit to children from reducing ambient PM2.5 emissions in Dhaka.” Allison Sherris, study lead author, postdoctoral research fellow in Earth system science at Stanford’s School of Earth, Energy & Environmental Sciences

For many of the 21 million residents of Dhaka, Bangladesh – the study’s focus area – air pollution is an all-too-regular part of life, especially in winter, when coal-burning brick kilns around the city operate. Of special concern is PM2.5, airborne particles 2.5 micrometers wide or smaller. The larger of these particles are about one-thirtieth the width of a human hair, small enough to inhale deep into the lungs.

Once inside the lungs, these particles can cause inflammation and impair the body’s ability to fight infection. But particles from different sources can have different shape, size and chemical composition, and it’s not clear what specific components of PM2.5 might be most harmful.

Few studies have evaluated the health effects of PM2.5 in infants and young children, especially in low-income countries where children are more than 60 times as likely to die from air pollution exposure as children in high-income countries, according to the World Bank. Among studies that have, most focused on the indoor environment, where the use of biomass-burning cookstoves has been associated with child respiratory infection.

“Specifying the impact of industry-generated air pollution on child health provides compelling evidence to support interventions to reduce pollution,” said study senior author Stephen Luby, a professor of infectious diseases at Stanford University. “This is often more salient to politicians than the marginal contribution of emissions to global climate change.”

Sherris, Luby and their colleagues analyzed long-term PM2.5 monitoring data alongside community health surveillance of respiratory infections from the Atomic Energy Centre, Dhaka, and the International Centre for Diarrhoeal Disease Research, Bangladesh. They found pneumonia incidence among children under 5 increased by 3.2 percent for every PM2.5 increase of 10 micrograms per cubic meter of air – a standard measure in air pollution analysis.

The mean PM2.5 level in Dhaka was on average over three times higher than the World Health Organization standard. The association between air pollution and child pneumonia suggests that air pollution is a major contributor to the leading cause of child death in Bangladesh and across South Asia.

That difference equates to more than 200,000 additional child pneumonia cases in Bangladesh each year, and nearly two million additional cases across South Asia. The increase is also approximately double similar prior estimates of pneumonia hospitalizations associated with increased PM2.5 and about 10 times more than such estimates for outpatient visits.

The difference from previous findings may reflect the young age of the study population – most children in the study were two or younger – the source composition of particulate matter in Dhaka, and the fact that the study included nearly all community infection cases, rather than just focusing on cases that made it to clinics and hospitals.

Prior studies by researchers at the Atomic Energy Centre, Dhaka found that biomass burning contributed the most to outdoor PM2.5 levels, followed by brick kiln emissions and soil dust. However, on days when brick kilns contributed a heavier than-usual amount of PM2.5 to the mix of bad air, the link between PM2.5 and child pneumonia was stronger.

The findings are among the first evidence that communities and policymakers can point to that suggests a measurable impact of brick kilns on child health. Considering 9 out of 10 people live in areas with air pollution exceeding World Health Organization guidelines, further investigation into whether particles from brick kilns and other sources have different health impacts could inform health and environmental interventions around the world. Luby leads a collaboration among public health experts, industry stakeholders, technology consultants and government agencies to improve the industry. He received funding for related work focused on brick kilns and other industries, funded by the Sustainability Initiative that gave rise to Stanford’s new school focused on climate and sustainability.

“We’re still only looking at a small slice of the potential health outcomes that might be linked to this kind of air pollution, and we still lack perfect measurements of exposure to it,” said Sherris. “The true health burden is likely much greater.

Study reveals a link between air pollution and child health
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Living near oil and gas wells increases air pollution exposure

Summary: Researchers found increased concentrations of air pollutants downwind from oil and gas wells in California, likely affecting millions of Californians who live near them.

In a 14-year analysis of air quality across California, Stanford researchers observed higher levels of air pollutants within 2.5 miles of oil and gas wells, likely worsening negative health outcomes for nearby residents.

The scientists analyzed local air quality measurements in combination with atmospheric data and found that oil and gas wells are emitting toxic particulate matter (PM2.5), carbon monoxide, nitrous oxide, ozone and volatile organic compounds (VOCs). The findings, which appear in the journal Science of the Total Environment, will help researchers determine how proximity to oil and gas wells may increase the risk of adverse health outcomes, including preterm birth, asthma and heart disease.

“In California, Black and Latinx communities face some of the highest pollution from oil and gas wells. If we care about environmental justice and making sure every kid has a chance to be healthy, we should care about this,” said lead author David Gonzalez, who conducted research for the study while a PhD student in Stanford’s Emmett Interdisciplinary Program in Environment and Resources (E-IPER). “What’s novel about our study is that we’ve done this at a population, state-wide scale using the same methods as public health studies.”

The findings align with other smaller-scale studies that have measured emissions from a handful of wells. At least two million Californians live within one mile of an active oil or gas well.

“It’s really hard to show air quality impacts of an activity like oil and gas production at a population scale, but that’s the scale we need to be able to infer health impacts,” said senior study author Marshall Burke, an associate professor of Earth system science at Stanford’s School of Earth, Energy & Environmental Sciences (Stanford Earth). “While it’s not necessarily surprising that drilling and operating oil and gas wells emit air pollutants, knowing the magnitude of the effect improves our broader understanding of who is exposed to what and how to intervene to improve health outcomes.”

A global killer

The research reveals that when a new well is being drilled or reaches 100 barrels of production per day, the deadly particle pollution known as PM2.5increases two micrograms per cubic meter about a mile away from the site. A recent study published in Science Advances found that long-term exposure to one additional microgram per meter cubed of PM2.5 increases the risk of death from COVID-19 by 11 percent.

“We started in 2006 because that’s when local agencies started reporting PM2.5 concentrations,” said Gonzalez, who is now a postdoctoral researcher at the University of California, Berkeley. “We’re very concerned about particulate matter because it’s a leading global killer.”

The team evaluated about 38,000 wells that were being drilled and 90,000 wells in production between 2006 and 2019. They developed an econometric model incorporating over a million daily observations from 314 air monitors in combination with global wind direction information from the National Oceanic and Atmospheric Administration (NOAA) to determine if the pollutants were coming from the wells.

Other factors that could be contributing to elevated emissions were controlled for — such as wildfire smoke or industrial activities — and monitors located far from drilling sites were used to identify those factors unrelated to wells. They also analyzed locations with air quality data from both before and after a well was drilled.

“Sometimes the wind is blowing from the well, sometimes it’s not, and we found significantly higher pollution on days when the wind is blowing from the wells,” Gonzalez said. “As a control, we assumed wells that are downwind of the air monitor shouldn’t contribute any pollution — and that is indeed what we saw.”

The research also reveals that ozone — a powerful oxidant that can cause wheezing, shortness of breath and aggravated lung disease — was present up to 2.5 miles from wells. Children are at the greatest risk from exposure to ozone because their lungs are still developing, according to the Environmental Protection Agency (EPA).

Chronic exposure

The new study contributes to a growing body of evidence about the dangers of living near oil and gas wells that may help guide ongoing policymaking around residential setbacks from drilling sites. For example, LA County recently voted to phase out oil and gas drilling, citing issues of climate change, environmental impacts and equity, and other California cities are in discussion about neighborhood drilling regulations.

“Many of California’s oil fields have been operating for decades. People that live near them have been chronically exposed to higher levels of pollution — and a lot of these wells are located in neighborhoods that are already burdened by pollution,” Gonzalez said. “Our study adds to the evidence that public health policies are needed to reduce residents’ exposure to air pollution from wells.”

Although data for the research is from California, the co-authors say the findings are likely applicable to other regions with oil and gas operations.

“We’ve had earlier papers suggesting that proximity to oil and gas production worsens health outcomes, and the likely channel was through air pollutants, but we previously didn’t have a good way to demonstrate that was the case,” Burke said. “This new work is helping confirm that air pollution was the missing link between this type of energy production and the bad outcome that we cared about.

Living near oil and gas wells increases air pollution exposure — ScienceDaily
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Air pollution caused 1.1 million deaths across Africa in 2019

A new study has linked air pollution to 1.1 million deaths across Africa in 2019. Pollution from indoor cookstoves was responsible for approximately 700,000 premature deaths, while outdoor air pollution was tied to 400,000 deaths. 

Dr. Philip Landrigan is a professor of Biology at Boston College, who led the project with United Nations Environment Programme Chief Environmental Economist Pushpam Kumar.

Dr. Landrigan said that while deaths from household air pollution have declined slightly, deaths caused by ambient air pollution (AAP) are on the rise.

“The most disturbing finding was the increase in deaths from ambient air pollution,” said Dr. Landrigan. “While this increase is still modest, it threatens to increase exponentially as African cities grow in the next two to three decades and the continent develops economically.”

The experts found that air pollution is costing African countries billions in gross domestic product. Poor air quality in Africa is also correlated with a devastating loss in the intellectual development of Africa’s children, according to the research.

“Air pollution in Africa has major negative impacts on health, human capital and the economy,” said the study co-authors. “These impacts are growing in magnitude as countries develop.”

“Experience from other countries suggests that the increases in AAP appearing in Africa today could be the harbinger of a looming problem.”

“In the absence of visionary leadership and intentional intervention, AAP could become a much larger cause of disease and premature death than at present and could pose a major threat to economic development.”

The study authors noted that Africa’s population is set to more than triple over the course of this century, jumping from 1.3 billion in 2020 to 4.3 billion by 2100. 

Overall, air pollution is one of the top two causes of death in Africa, second only to AIDS.

“We encourage Africa’s leaders to take advantage of the fact that their countries are still relatively early in their economic development and to transition rapidly to wind and solar energy, thus avoiding entrapment in fossil-fuel-based economies,” said Dr. Landrigan.  “

We argue that African countries are in a unique position to leapfrog over mistakes made elsewhere and to achieve prosperity without pollution.”

“Air pollution in Africa threatens economic development and future growth, but can be avoided by wise leaders who transition rapidly to wind and solar energy and avoid entrapment by coal, gas and oil.”

The study is published in the journal The Lancet Planetary Health.

Air pollution caused 1.1 million deaths across Africa in 2019 • Earth.com
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Farm fires from Pakistan to add increased air pollution load for Delhi

Satellite images by NASA have shown the increasing instances of farm fires vis vis stubble burning not just in Punjab and Haryana in the Indian side but also over large areas in Pakistan to the west of Punjab.

A NASA satellite image tweeted on Saturday morning by India Meteorology Department (IMD) scientist Ashim Mitra shows clusters of red dots (denoting farm fires) spread across Punjab and Haryana and also in Pakistan.

Despite several efforts by the Central and state governments to prevent farm fires, scores of farmers in Punjab and Haryana have started stubble burning ahead of the rabi season, air pollution from which is soon likely to travel towards Delhi-NCR.

The only saving grace for this week is that the number of fire counts is still very less and there are strong winds that dissipate this pollution faster. “The impact of these farm fires will not be felt much this week as the wind speed is strong and the number of fires is less,” IMD scientist in Delhi Urban Meteorological Services, Dr V.K. Soni said.

The IMD issues a forecast for three days and seven days outlook. Accordingly, there would be strong winds for next two days and there is no chance of rain.

But whatever little impact that these fires can have is already visible in the Air Quality Index (AQI) by the Central Pollution Control Board in the national capital. The AQI at 7 p.m. on Sunday at Anand Vihar was already at 289, Wazirpur was at 230, and Jahangirpuri at 197. At Shadipur, it was 189, at Okhla, it was 172, at Punjabi Bagh it was 166, and even at Lodi Road it was 140.

The Commission for Air Quality Management (CAQM) has been issuing a number of guidelines, the Delhi government has taken a number of initiatives to control dust and other pollutants and the Central government has said, it has provided harvester machines in large numbers for the farmers of Punjab and Haryana so that the stubble left from the kharif crop is not burnt.

Farm fires from Pakistan to add increased air pollution loa… | MENAFN.COM
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Clean air matters for a healthy brain: Research on air pollution and cognitive decline indicate cleaner air may reduce risk for Alzheimer’s and other dementias

Two USC researchers whose work linked air pollution to a greater risk of Alzheimer’s disease and faster cognitive decline are seeing signs that cleaner air can make a difference in brain health.

Cars and factories produce a fine particulate known as PM2.5 that USC-led studies have linked to memory loss and Alzheimer’s disease. Smaller than the width of a human hair, these tiny particles pose a big problem. Once inhaled, they pass directly from the nose up and into the brain, beyond the blood-brain barrier that normally protects the brain from dust or other invaders.

In a research letter published today in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, the USC researchers described how their labs each independently reported indications of recent decreases in neurotoxicity (damage to the brain or nervous system caused by exposure to toxic substances) of PM2.5 air pollution in humans and mice.

University Professor Caleb Finch and associate professor of gerontology and sociology Jennifer Ailshire, both with the USC Leonard Davis School of Gerontology, focused on PM2.5 pollution. Long-term exposure to PM2.5 has been linked to premature death, particularly in people with chronic heart or lung diseases.

Ailshire’s research, published earlier this year in the Journal of Alzheimer’s Disease, showed a strong association between cognitive deficits and air pollution among people with lower levels of education in 2004.

Based on data from the nationwide Health and Retirement Study, her work showed that, when exposed to PM2.5, adults 65 and older who had fewer than eight years of education faced a greater risk of cognitive impairment. But one decade later, Ailshire found no such association for study participants.

A likely factor was the reduction in PM2.5 over the prior decade, said Ailshire. Air quality data showed the average annual PM2.5 levels in the study participants’ neighborhoods were 25% below 2004 levels.

Notably in 2014, very few of the study participants lived in places with annual average PM2.5 that exceeded U.S. Environmental Protection Agency air quality standards. This further suggested that the improvements with cognitive decline were linked to a drop in exposure to high pollution among older adults.

“Improving air quality around the country has been a tremendous public health and environment policy success story. But there are signs of a reversal in these trends,” Ailshire said. “Pollution levels are creeping up again and there are increasingly more large fires, which generate a significant amount of air pollution in certain parts of the country. This gives me cause for concern about future trends in improving air quality.”

Finch’s research on mice, published earlier this year in the Journal of Alzheimer’s Disease, also found evidence of lower neurotoxicity of air pollution over time. Finch and his research team have studied pollution levels at the same Los Angeles site and their effect on mouse brains since 2009. After 2017, the mice exposed to a tiny, nanoscale version of PM2.5 appeared healthier. Markedly, they showed sharp declines in several factors of neurotoxicity, including oxidative damage to cells and tissues.

During the years that Finch’s and Ailshire’s studies were taking place, the composition of air pollution in the United States was also changing.

From 2000 to 2020, PM2.5 levels declined nationwide by 41%, according to the EPA. In contrast, urban PM2.5 in Los Angeles declined only slightly from 2009 to 2019. While nationwide ozone levels decreased, Los Angeles County ozone reversed the prior trends by increasing after 2015.

Finch and Ailshire emphasize that their findings cannot evaluate potential benefits of air pollution improvements to the risk of cognitive decline and dementia. Although PM2.5 levels declined nationally from 2009 to 2016, the year-over-year increases that have been observed since 2017 show that improvements in air quality can be reversed, as they were in Los Angeles.

“Our findings underscore the importance of efforts to improve air quality as well as the continued importance of demographic and experimental evaluation of air pollution neurotoxicity,” Finch said.

Finch and Jiu-Chiuan “J.C.” Chen, an associate professor of preventive medicine at the Keck School of Medicine of USC, previously published a study using both human and animal data that showed brain aging processes worsened by air pollution may increase dementia risk. Their research indicated that older women who lived in locations with high levels of PM2.5 suffered memory loss and Alzheimer’s-like brain shrinkage not seen in women living with cleaner air.

Clean air matters for a healthy brain: Research on air pollution and cognitive decline indicate cleaner air may reduce risk for Alzheimer’s and other dementias — ScienceDaily
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