Why Do Some People Itch So Much? The Answer Is In The Air 

Researchers from the Tohoku University Graduate School of Medicine and Tohoku Medical Megabank Organization in Japan have discovered why air pollutants cause some people to be more susceptible to atopic dermatitis, a kind of skin inflammation. Their work was published in Nature Immunology.

While the correlation between air pollution and the prevalence and severity of atopic dermatitis is well-known, the underlying mechanism was not widely understood. AhR, a transcription factor activated by air pollutants, causes hypersensitivity to itch through the expression of the neurotrophic factor artemin, according to Dr. Masayuki Yamamoto, who led the research team with Drs. Takanori Hidaka and Eri Kobayashi.

“Scratching makes things worse because the skin barrier gets disrupted and sensitization to antigens is enhanced. That’s why some people are predisposed to atopic dermatitis,” said Yamamoto.

In human clinical samples, the researchers observed high levels of AhR activation and artemin expression in atopic dermatitis patients, but not in healthy individuals. This is also consistent with the findings in a similar study of mice, and further supports the notion that chronic activation of AhR is an important environmental factor causing atopic dermatitis.

Currently, steroid drugs are used as a symptomatic treatment for atopic dermatitis. However, in some cases, the itch remains. The research team believes that control of the itch is important and hopes that with the results of this study, new treatments using inhibitors of AhR and/or artemin can be found.

The article can be found at: Hidaka et al. (2016) The Aryl Hydrocarbon Receptor AhR Links Atopic Dermatitis and Air Pollution via Induction of the Neurotrophic Factor Artemin. Read more from Asian Scientist Magazine at: http://www.asianscientist.com/2016/11/in-the-lab/air-pollutants-atopic-dermatitis/

Source: Why Do Some People Itch So Much? The Answer Is In The Air | Asian Scientist Magazine | Science, Technology and Medicine News Updates From Asia

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Study reveals why air pollutants cause some people to be at risk for atopic dermatitis

Tohoku University Graduate School of Medicine and Tohoku Medical Megabank Organization (ToMMo) are pleased to announce the published results of a study into why air pollutants cause some people to be more susceptible to atopic dermatitis, a kind of skin inflammation.

“We have discovered that AhR, a transcription factor activated by air pollutants, causes hypersensitivity to itch, through the expression of neurotrophic factor artemin,” says Dr. Masayuki Yamamoto, who led the research team with Drs. Takanori Hidaka and Eri Kobayashi. “Scratching makes things worse because the skin barrier gets disrupted and sensitization to antigens is enhanced. That’s why some people are predisposed to atopic dermatitis.

While the correlation between air pollution and the prevalence and severity of atopic dermatitis is well known, the underlying mechanism behind it was not widely understood, until now.

Itch causes scratching, which disrupts the skin barrier function, making it easy for antigens to penetrate. This results in the patients being sensitized to antigens and predisposed to allergic diseases such as asthma. This is known as “the allergic march,” and is observed in patients with atopic dermatitis.

In human clinical samples, high levels of AhR activation and artemin expression are observed in atopic dermatitis patients but not in healthy individuals. This is also consistent with the findings in a similar study of mice, and further supports the notion that chronic activation of AhR is an important environmental factor causing atopic dermatitis.

Currently, steroid drugs are used as a symptomatic treatment for atopic dermatitis. However, in some cases, the itch remains. The research team believes that control of the itch is important and hopes that with the results of this study, new treatments using inhibitors of AhR and/or artemin can be found.

Source: Study reveals why air pollutants cause some people to be at risk for atopic dermatitis

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Air pollution export map reveals where to target clean-up

Take any city in the UK, and you’ll likely find that the skies are cleaner today than they were 40 years ago. Sophisticated scrubbers on power station chimneys, catalytic converters on vehicle exhausts and cleaner fuels have all helped to reduce the haze. But it isn’t just cleaning up at home that has made our skies clearer; we’ve also been outsourcing much of our dirty work to other countries. For the first time, a study shows exactly how much air pollution each country is exporting, and where it is exporting it to.

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For those of us living in developed countries it is common to be surrounded by imported goods. The car parked outside your house, your laptop, camera and smartphone, the food you are preparing for dinner, and even the chair you are sitting on may well have originated many hundreds of miles away. Some of those goods will have been produced responsibly, whilst others will have added to the choking smogs that frequent cities like Tianjin in China.

Although it has long been known that high-income countries are responsible for a significant share of the pollution burden in developing countries, it has always been hard to map out exactly where air pollution is being exported to. To resolve this, Daniel Moran from the Norwegian University of Science and Technology and Keiichiro Kanemoto from Shinshu University in Japan used air pollution maps and trade databases from 187 countries to model the link between severe air pollution hotspots and global supply chains. In particular they modelled the spatial patterns of sulphur dioxide, nitrogen oxides and PM10 particles, and assessed how these had changed over time.

The results clearly show that the US and European countries have achieved impressive emissions reductions at home, but at the same time have significantly increased their pollution footprint abroad. “We anticipated this spatial spread, but the volume of emissions exported was far higher than we had expected,” said Kanemoto, whose findings are published in Environmental Research Letters (ERL).

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Perhaps not surprisingly, the team found that China bears the greatest pollution burden for other countries, with India not far behind. Meanwhile, the US and countries across Europe are guilty of offloading some of the largest pollution burdens onto others. “The UK, for example, has increased imports from China and other countries to satisfy its consumption,” said Kanemoto. “This alleviates the UK’s domestic air pollution but drives growth in global air pollution.”

Over time, the rapid growth in consumption in developed countries appears to have massively increased their air pollution footprints. For example, Kanemoto and Moran show that in 1970, 90% of the US sulphur dioxide footprint rested in just 1.5% of global land area. By 2008 the footprint extent had doubled to 3.1% of global land area. The equivalent NOx footprint growth for the US has been even more dramatic, rising from 0.6% to 3.6% of global land area over the same time period, and PM10 worse still, growing 15-fold to 9.9% of global land area by 2008.

But the new pollution export maps could help to identity the most effective abatement opportunities and focus clean-up efforts. Kanemoto and Moran show that if the US targeted clean-up in the 1% of land area where its air pollution footprint falls most heavily, those efforts could reach 80% of its sulphur dioxide and NOx footprints, and 55% of its PM10 footprint.

“We hope that identifying hotspots linked to trade will help and encourage the down-stream users – companies, countries and individuals – to participate in clean-up measures at those hotspots,” said Kanemoto.

Source: Air pollution export map reveals where to target clean-up – environmentalresearchweb

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Department warns of high pollution levels in Belfast and Londonderry 

High levels of air pollution are being monitored by Department of Environment officials in Belfast and Londonderry.

Moderate levels are also being recorded in towns across Northern Ireland.

The department said “elevated levels” of pollution are likely to continue for as long as the cold and calm weather conditions persist.

The levels are believed to be as a result of local pollution sources like cars and home heating emissions.

The calm weather conditions are exacerbating the problem, because pollutants are not being widely dispersed by wind.

Hourly updates

During periods of high pollution, people with lung or heart disease may find their symptoms worsening.

Healthy people are unlikely to experience any ill effects.

Hourly updates on levels of particulate matter, sulphur dioxide, nitrogen dioxide, ozone and carbon monoxide are available on the Department’s website.

There is also an SMS service, Air Aware, which members of the public can subscribe to if they want to receive direct notification of high air pollution episodes.

Source: Department warns of high pollution levels in Belfast and Londonderry – BBC News

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UK has second-highest number of deaths from NO2 pollution in Europe

Only Italy has more annual deaths from nitrogen dioxide, according to a report by the European Environment Agency

The UK is second only to Italy in Europe for the highest number of annual deaths from a major air pollutant, a report has found just days after a court gave UK ministers a deadline for drawing up a stronger air quality plan.

The European Environment Agency said the UK had 11,940 premature deaths in 2013 from nitrogen dioxide (NO2), a toxic gas mostly caused by diesel vehicles and linked to lung problems. The number is down from 14,100 in 2012, but still the second worst in Europe.

The agency also revealed that the UK is home to the worst NO2 hotspot in Europe. Marylebone Road in London recorded the highest annual mean levels of the pollutant, more than double than double the legal EU limit.

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Campaigners said the data was a reminder that the UK, which has been in breach of EU limits on NO2 since 2010, needed to take tougher action.

James Thornton, the CEO of law firm ClientEarth, which brought the court case, said: “Today’s EEA report puts the UK in an unwanted position near the top of the table when it comes to premature deaths from exposure to NO2 pollution. The UK government should be ashamed of these figures and must act now to protect the health of people in this country.”

Italy and UK both a similar proportion of diesel cars, but the NO2 problem in Italy is also compounded by industrial sources of the pollutant in urban and suburban areas, experts at the EEA said.

Across Europe, the EEA estimated that 71,000 people died prematurely in 2013 because of NO2 pollution. While the pollutant has been on a downward trend since the turn of the century because of stricter diesel car standards, more than one in 10 monitoring stations in Europe still breach NO2 limits, the agency found.

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Hans Bruyninckx, the EEA’s executive director, said: “Emission reductions have led to improvements in air quality in Europe, but not enough to avoid unacceptable damage to human health and the environment.”

The report comes as MEPs in the European parliament on Wednesday arpproved caps for five air pollutants, including NO2, to come into force in 2030. The new national emissions ceilings rules are expected to halve the number of deaths from air pollution.

Catherine Bearder, a Liberal Democrat MEP, said: “If I had become a doctor instead of a politician I would be prescribing a serious health warning to the UK government today. The UK government have approved a third runway at Heathrow airport even though they know that air pollution around the airport is already dangerously above legal levels of nitrogen dioxide.”

The Guardian reported earlier this year that the plan had been diluted after lobbying by the UK government.

Source: UK has second-highest number of deaths from NO2 pollution in Europe | Environment | The Guardian

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Air pollution ’causes 467,000 premature deaths a year in Europe’

Air pollution is causing around 467,000 premature deaths in Europe every year, the European Environment Agency (EEA) has warned.

People in urban areas are especially at risk, with around 85% exposed to fine particulate matter (PM2.5) at levels deemed harmful by the World Health Organization (WHO).

These particles are too small to see or smell, but have a devastating impact.

PM2.5 can cause or aggravate heart disease, asthma and lung cancer.

How big is the problem?

It’s pretty bad. Within the European Union (EU), more than 430,000 people died prematurely due to PM2.5 in 2013, the most recent year with figures available.

According to the EEA’s Air quality in Europe – 2016 report, the toxic gas nitrogen dioxide (NO2) – released by vehicles and central heating boilers – has an impact equivalent to 71,000 premature deaths a year.

Ground-level ozone (O3) is also killing people – an estimated 17,000 annually in the EU.

Unlike the protective ozone layer in the stratosphere, ground-level ozone is harmful, formed when emissions like NO2 react with other pollutants and “cook” in heat or sunlight.

The European countries with the worst levels of PM2.5 are Bulgaria, Poland and the Czech Republic.

Nations like Poland where coal is a major source of electricity production tend to rank at the bottom of air quality measures, according to the EEA.

In 2013, Bulgaria provided four of the five worst European cities for high particulate matter. Costs to ill-health from coal power plants in the country are estimated to be up to €4.6bn ($4.8bn; £3.9bn) per year.

In the UK, air pollution overall costs the economy more than £20bn per year – just under 16% of the NHS’s annual £116bn budget.

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Technically, European air quality actually improved between 2000 and 2014. Levels of PM10 – another tiny pollutant particle – fell in 75% of the EEA’s monitored locations.

PM2.5 concentrations also dropped on average between 2006 and 2014.

But EEA executive director Hans Bruyninckx says “unacceptable damage to human health and the environment” is still rife.

Outdoor air pollution contributes to about 40,000 early deaths a year in the UK, according to the Royal Colleges of Physicians and of Paediatrics and Child Health.

Source: Air pollution ’causes 467,000 premature deaths a year in Europe’ – BBC News

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Smog gets in your eyes 

Lahore has experienced smog for the past five years: in 2014, it ranked amongst the top 10 worst cities for smog according to a Deutsche Welle report.

This November, its intensity exposed the lack of effective planning by the city management and local administration.

Heavy smog brought a disastrous impact on daily life with traffic coming to a halt on motorways in the early office hours and after sunset due to dangerously low visibility. People complained of eye-irritation, coughing and asthma.

Lahore is a semi-industrial city comprising small and large-scale industrial units. Heavy traffic and on-going mega projects such as the Orange Line together produce significant pollution throughout the year.

In the surrounding cities of Kasur, Sheikhupura and Pindi Bhattian, around November, farmers burn their agricultural leftover sending a lot of smoke into the atmosphere. Crop residue can be disposed of in a sustainable way, but the cost is too high for the farming community.

The combined smoke from industries, traffic and crop-burning is normally washed away when it rains in winter, but this year, due to an early winter and no rain, this pollution and smoke has converted into smog causing low visibility and health issues for the residents.

According to Dr Qamar-uz-Zaman Chaudhry, former director general of the Pakistan Meteorological Department, “Climate change has affected the climate cycle creating an extended dry cycle, which causes smog.”

However, Dr Adil Najam, Dean of the Pardee School of Global Studies at Boston University believes that climate change is not the only factor.

“This is much more a case of pollution. We have had a double whammy because pollution, especially from vehicles, has gone up while trees and vegetation have steadily gone down. What we are seeing is the combined effect of these two dynamics coupled with the weather pattern,” he points out.

What is smog made up of and how will it affect you?

Lahore experiences a photochemical smog which is a mixture of primary and secondary pollutants.

Primary pollutants are released into the atmosphere because of human activity while secondary pollutants are produced when primary pollutants react with each other or with the air in the presence of sunlight.

The primary air pollutants of smog are mainly composed of anthropogenic gases (gases resulting from human activity) including nitrogen oxides, sulphur dioxide, carbon monoxide, hydrocarbons and particulate matter (extremely small particles combined with water droplets which can cause serious health problems when inhaled).

When these pollutants interact with damp air in cold weather a layer of thick smoke is formed near the earth’s surface. The thicker the smoke is, the higher the concentration of toxic gases and particles.

Pakistan has no real-time air quality monitoring system for on-site monitoring of its polluted cities.

However, some measurements taken during smoggy days show a concentration of pollutants much higher than those recommended by the National Environmental Quality Standards.

Exposure to smog for long hours can cause serious health issues — it can cause chest congestion, irritation in our respiratory system, reduce lung function and aggravate asthma. It also affects the immune system of animals to fight against harmful bacteria in the respiratory tract.

According to Dr Kashif Raza Khan, ophthalmologist at King Edward Medical University, exposure to smog can cause short-term eye-burning which can be treated by washing the eyes with water. Using a mask is recommended especially for motorcyclists.

What caused the current smog?

While the current smog over Lahore is being attributed primarily to crop burning, there are multiple sources of smog production.

A World Bank study revealed that from November 2005 to January 2006, several contributing factors were responsible for the high particulate matter in the air such as diesel emissions (28 per cent), biomass burning (15pc), coal combustion (13pc), secondary particulate matter (30pc), exhaust from two-stroke vehicles (8pc), and industrial sources (6pc).

The biggest culprits were diesel and emissions from motorcycles and rickshaws which accounted for 36pc of the high particulate matter.

Although a large component of the carbonaceous aerosols in Lahore originated from fossil fuel combustion, a significant fraction was derived from biomass burning.

What the government needs to do

Tackling pollution caused by vehicles will be the biggest headache for authorities. The number of vehicles in Pakistan has jumped from approximately two million to 10.6mn over the last 20 years, an average annual growth rate in excess of 8.5pc.

From 1991 to 2012, the number of motorcycles and scooters grew more than 450pc, and motor cars close to 650pc.

Industrial sites and factories such as brick kilns and steel mills located within city limits are also a contributing factor.

The government can turn to the courts for a solution

Pakistan’s judiciary has often dealt with environmental conservation, such as the establishment of Lahore Clean Air Commission by the Lahore High Court (LHC) which was assigned to prepare and submit a report to measure, control and improve vehicular air pollution in the city.

There are also reports of open-field burning of rice straw across the border in the Indian Punjab region which has aggravated smog in Lahore as reported by Nasa.

According to environmental lawyer, Ahmed Rafay Alam, Pakistan can hold India liable for the current smog but only if the government can prove its neighbouring country is responsible.

“If we can prove that crop burning in India has exacerbated smog on the Pakistani side, then under International Environmental Law, India can be made liable to prevent this from happening again. But without adequate testing equipment, we can’t be sure and no policy can be set.”

What Lahore can learn from other cities

For solutions to the current smog, the Lahore administration need not look further than it’s neighbouring country. In the past week and a half, New Delhi has faced poor air quality — the Air Quality Index value reached 999 on the index (a value above 300+ is considered ‘hazardous’) due to unchecked crop burning and the use of firecrackers during Diwali.

The local administration in New Delhi took immediate measures such as closures of schools to prevent children from being exposed to toxic air, the shutting down of the coal-fired Badarpur Thermal Power plant, banning of all construction and demolition work and a ban on burning trash at landfill sites.

For traffic control, an odd/even numbering system is being considered. Vacuum cleaning is also being done on highways to clean the air while artificial rain is also under consideration. The steps being taken by the New Delhi administration could be followed by Lahore’s.

Other long-term solutions include real-time air quality monitoring devices at various locations in the city, shifting heavily polluting industries outside the city, planting trees, sufficient public transport and sustainable management of agricultural waste residue can provide long-term solutions to smog.

If the authorities don’t take action soon, Lahore might go the way of London.

The Great Smog of 1952 — also known as The Big Smoke — when the city suffered from five days of smog which led to the deaths of 4,000 people (updated figures reveal the number of fatalities could have been as great as 12,000) and the hospitalisation of another 100,000.

The Great Smog eventually led to the enactment of the Clean Air Act 1956. If we fail to learn, the time is not far when the rivers will go dry, all trees will be chopped down and the air will be impossible to breathe. Only then we will realise, we can’t eat money!

Source: Smog gets in your eyes – Magazine – DAWN.COM

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Antimicrobial resistant bacteria detected in air pollution

Areas subject to air pollution contain a growing concentration of bacteria that are resistant to antimicrobials, according to a new study. Consequently, air movement may provide a new ways for their transmission.

The study, highlighting a growth in airborne or air-carried antimicrobial resistant bacteria, has come from China, with a focus on the Beijing. The extent of antimicrobial resistance has been assessed at the genetic level, with the detection of DNA from genes that make bacteria resistant.

The study has been led by Professor Joakim Larsson, of the Sahlgrenska Academy and the University of Gothenburg. Professor Larsson is especially concerned about air as a potential vector for spreading antimicrobial resistant pathogens.

Antimicrobial resistance (including resistance to antibiotics) is the biggest risk faced by human societies. The implications are that life expectancy could fall due to people dying from diseases that are readily treatable today.

With the new research, Professor Larsson’s team tested air samples for genes that make bacteria resistant to antibiotics. From a total of 864 samples, DNA was tested and related back to its source. One area of concern was the detection of a series of genes that provide resistance to carbapenems. These are a group of ‘last resort antibiotics’ and they are administered for infections caused by bacteria that the most resistant to antimicrobials. Carbapenems are members of the beta lactam class of antibiotics, which kill bacteria by binding to penicillin-binding proteins and inhibiting cell wall synthesis.

Importantly, the findings cannot indicate if the bacteria are alive in the air. This narrows the risk somewhat; however, the potential for genetic transfer with viable bacteria, upon contact, remains.

The study is, however, only a starting point. The researchers plan to assess whether antimicrobial resistance can indeed spread through air. Here the focus will move to a study of the air within the vicinity of European sewage treatment plants. Sewage plants are regularly called out as potential sites for the spread of antimicrobial resistance. This is because, with so many different types of bacteria coming together in sewage plants, this provided optimal conditions for organisms to swap genes that confer resistance. This also means antibiotic-resistant bacteria could evolve much faster than they would in isolation.

Data will be cross-checked in relation to the air and to the sewage. Additional samples will be taken from people who live in close proximity to sewage plants.

The research findings are published in the journal Microbiome and the research paper is titled “The structure and diversity of human, animal and environmental resistomes.”

Source: Antimicrobial resistant bacteria detected in air pollution

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